hTERT gene expression regulatory gene

Details hTERT gene expression regulatory gene hTERT gene expression regulatory gene

2011-07-26

2011-07-26

Schnizer, Richard (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100

Reexamination Certificate

active

07985852

ABSTRACT:
Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal. A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression of a telomerase reverse transcriptase gene can be inhibited by inhibiting the expression of the gene. By utilizing this mechanism, the expression of a telomerase reverse transcriptase gene can be regulated.

REFERENCES:
patent: 2003/0144232 (2003-07-01), Agami et al.
patent: 2003/0144239 (2003-07-01), Agami et al.
patent: 2007/0031844 (2007-02-01), Khvorova et al.
patent: 2 383 330 (2003-06-01), None
patent: 2004-350607 (2004-12-01), None
patent: 2005-512596 (2005-05-01), None
patent: 2005-524393 (2005-08-01), None
patent: 03/056012 (2003-07-01), None
patent: 03/070744 (2003-08-01), None
patent: 2004/048566 (2004-06-01), None
GenBank AL355591, Jun. 20, 2002.
Peck, A.: Title: Direct Submission, Definition: Human DNA sequence from clone RP110-300b7 on chromosome 10 Contains a CpG island, complete sequence; dated Apr. 30, 2008; Database EMBL Jun. 21, 2002, XP002487838, Database accession No. al355591.
“Supplementary European Search Report” dated Jun. 21, 2002 (EP 06 73 0286).
Arata Nishimoto et al., “Functional evidence for a telomerase repressor gene on human chromosome 10p15.1,” Oncogene, 2001, vol. 20, No. 7, pp. 828-835.
Hiromi Tanaka et al., “Evidence for a putative telomerase repressor gene in the 3p142-p21.1 Region,” Genes, Chromosomes & Cancer, 1998, vol. 23, No. 2, pp. 123-133.
Joseph C. Poole et al., “Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT),” Gene, 2001, vol. 269, Nos. 1 and 2, pp. 1-12.
Shuwen Wang et al., “Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter,” The Journal of Biological Chemistry, 2003, vol. 278, No. 21, pp. 18842-18850.
Jaejoon Won et al., “Opposing regulatory roles of E2F in human telomerase reverse transcriptase (hTERT) gene expression in human tumor and normal somatic cells,” FASEB.J., 2002, vol. 16, No. 14, pp. 1943-1945.
Ahmet M. Denli et al., “Processing of primary microRNAs by the microprocessor complex,” Letters to Nature, 2004, vol. 432, No. 7014, pp. 231-235.

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