HT.sub.m4 methods of treatment and assays, agonists and antagoni

Details HT.sub.m4 methods of treatment and assays, agonists and antagoni HT.sub.m4 methods of treatment and assays, agonists and antagoni

1997-12-19

1999-10-26

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4353201, 536 235, C12N 1500, C12N 120, C07H 2104

Patent

active

059726881

ABSTRACT:
The invention relates to a recombinant DNA molecule which encodes a HT.sub.m4 protein, a transformed host cell which has been stably transfected with a DNA molecule which encodes a HT.sub.m4 protein and a recombinant HT.sub.m4 protein. The invention also relates to a method for detecting the presence of a hereditary atopy.

REFERENCES:
Stedman's Medical Dictionary, 26th edition, Williams & Wilkins (Baltimore, MD), p. 613, 1995.
Hannon, Gregory J. et al., "KAP: A Dual Specificity Phosphatase that Interacts with Cyclin-Dependent Kinases," Proc. Natl. Acad. Sci. USA, vol. 91:1731-1735 (1994).
Rothe, Mike et al., "A Novel Family of Putative Signal Transducers Associated with the Cytoplasmic Domain of the 75 kDa Tumor Necrosis Factor Receptor," Cell, vol. 78:681-692 (1994).
Gyuris, Jeno et al., "Cdil, a Human G1 and S Phase Protein Phosphatase that Associates with Cdk2," Cell, vol. 75:791-803 (1993).
Shirakawa, Taro et al., "Association Between Atopy and Variants of the .beta. Subunit of the High-affinity Immunoglobulin E Receptor," Nature Genetics, vol. 7:125-130 (1994).
Marsh, David G. and Meyers, Deborah A., "A Major Gene for Allergy--Fact or Fancy?," Nature Genetics, vol. 2:252-254 (1992).
Cookson, William O.C.M. et al., "Linkage Between Immunoglobulin E Responses Underlying Asthma and Rhinitis and Chromosome 11q," The Lancet, 1292-1295 (1989).
Ravetch, Jeffrey V. and Kinet, Jean-Pierre, "Fc Receptors," Annu. Rev. Immunol., vol. 9:457-492 (1991).
Ra, Chisei et al., "Complete Structure of the Mouse Mast Cell Receptor for IgE (Fc.epsilon.RI) and Surface Expression of Chimeric Receptors (Rat-Mouse-Human) on Transfected Cells," J. Biol. Chem., vol. 264 (26):15323-15327 (1989).
Maekawa, Kazuhiko et al., "Determination of the Sequence Coding for the .beta. Subunit of the Human High-affinity IgE Receptor," FEBS Lett., vol. 302(2):161-165 (1992).
Davies, Kevin, "Allergy by Mutation," Nature, vol. 369:506 (1994).
Kuster, Helmut et al., "The Gene and cDNA for the Human Affinity Immunoglobulin E Receptor .beta. Chain and Expression of the Complete Human Receptor," J. Biol. Chem., vol. 267(18):12782-12787 (1992).
Mosialos, George et al., "The Epstein-Barr Virus Transforming Protein LMP1 Engages Signaling Proteins for the Tumor Necrosis Factor Receptor Family," Cell, vol. 80:389-399 (1995).
Poon, Randy Y.C. and Hunter, Tony, "Dephosphorylation of Cdk2 Thr.sup.160 by the Cyclin-Dependent Kinase-Interacting Phosphatase KAP in the Absence of Cyclin," Science, vol. 270:90-93 (1995).
Kobayashi, Hirofumi et al., "Variability of 11q23 Rearrangements in Hematopoietic Cell Lines Identified with Fluorescence In Situ Hybridization," Blood, vol. 81(11):3027-3033 (1993).
Cookson, William O.C.M. et al., "Maternal Inheritence of Atopic IgE Responsiveness on Chromosome 11q," The Lancet, vol. 340(8816):381-384 (1992).
Ravetch, Jeffrey V., "Atopy and Fc Receptors: Mutation in the Message?," Nature Genetics, vol. 7:117-118 (1994).
Fields, Stanley and Song, Ok-kyu, "A Novel Genetic System to Detect Protein-Protein Interactions," Nature, vol. 340:245-246 (1989).
Yang, Xiaolu et al., "A Protein Kinase Substrate Identified by the Two-Hybrid System," Science, vol. 257:680-682 (1992).
Cheng, Genhong et al., "Involvement of CRAF1, A Relative of TRAF, in CD40 Signaling," Science, vol. 267:1494-1498 (1995).
Sebastian, Byron et al., "Cdc25M2 Activation of Cyclin-Dependent Kinases by Dephosphorylation of Threonine-14 and Tyrosine-15," Proc. Natl. Acad. Sci. USA, vol. 90:3521-3524 (1993).
Hakes, David J. et al., "A Protein Phosphatase Related to the Vaccinia Virus VH1 is Encoded in the Genomes of Several Orthopoxviruses and a Baculovirus," Proc. Natl. Acad. Sci. USA, vol. 90:4017-4021 (1993).
Harper, J.W. et al., "The P21 Cdk-Interacting Protein cip 1 is a Potent Inhibitor of G1 Cyclin-Dependent Kinases," Cell, vol. 75:805-816 (1993).
Kinet, Jean-Pierre et al., "Isolation and Characterization of cDNAs Coding for the .beta. Subunit of the High-Affinity Receptor for Immunoglobulin E," Proc. Natl. Acad. Sci. USA, vol. 85:6483-6487 (1988).
Adra, Chaker N. et al., "Cloning of the cDNA for a Hematopoietic Cell-Specific Protein Related to CD20 and the .beta. Subunit of the High-Affinity IgE Receptor: Evidence for a Family of Proteins With Four Membrane-spanning Regions," Proc. Natl. Acad. Sci. USA, vol. 91:10178-10182 (1994).
Galaktionov, Konstantin and Beach, David, "Specific Activation of cdc25 Tyrosine Phosphatases by B-Type Cyclins: Evidence for Multiple Roles of Mitotic Cyclins," Cell, vol. 67:1181-1194 (1991).
Wright, Mark D. and Tomlinson, Michael G., "The Ins and Outs of The Transmembrane 4 Superfamily," Immunology Today, vol. 15, No. 12:588-594 (1994).
Haas, Rainer et al., "Successful Autologous Transplantation of Blood Stem Cells Mobilized with Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor," Experimental Hematology, vol. 18:94-98 (1990).
Berardi, Anna C. et al., "Functional Isolation and Characterization of Human Hematopoietic Stem Cells," Science, vol. 267:104-108 (1995).
Huang, Shiang and Terstappen, Leon W.M.M., "Lymphoid and Myeloid Differentiation of Single Human CD34.sup.+, HLA-DR.sup.+, CD38.sup.- Hematopoietic Stem Cells," Blood, vol. 83, No. 6:1515-1526 (1994).
Fleming, William H. et al., "Functional Heterogeneity Is Associated with the Cell Cycle Status of Murine Hematopoietic Stem Cells," J. of Cell Bio., vol. 122, No. 4:897-902 (1993).
Roberts, Andrew W. and Metcalf, Donald, "Noncycling State of Peripheral Blood Progenitor Cells Mobilized by Granulocyte Colony-Stimulating Factor and Other Cytokines," Blood, vol. 86, No. 4:1600-1605 (1995).
Reems, Jo Anna and Torok-Storb, Beverly, "Cell Cycle and Functional Differences Between CD34.sup.+ /CD38.sup.hi and CD34.sup.+ /38.sup.lo and Human Marrow Cells After In Vitro Cytokine Exposure," Blood, vol. 85, No. 6:1480-1487 (1995).
Takeuchi, Masahiro et al., "Anatomy of TRAF2," J. of Bio. Chem., vol. 271, No. 33:19935-19942 (1996).
Rothe, Mike et al., "TRAF2-Mediated Activation of NF-KB by TNF Receptor 2 and CD40," Science, vol. 269:1424-1427 (1995).
Barinaga, Marcia, "Forging a Path to Cell Death," Science, vol. 273:735-737 (1996).
Smith, Craig A. et al., "The TNF Receptor Superfamily of Cellular and Viral Proteins: Activation, Costimulation, and Death," Cell, vol. 76:959-962 (1994).
Cao, Zhaodan, et al., "TRAF6 is a Signal Transducer for Interleukin-1," Nature, vol. 383:443-446 (1996).
Ando, Kiyoshi et al., "Regulation of G.sub.1 /S Transition by Cyclins D2 and D3 In Hematopoietic Cells," Proc. Natl. Acad. Sci. USA, vol. 90:9571-9575 (1993).
Spangrude, Gerald J. et al., "Purification and characterization of Mouse Hematopoietic Stem Cells," Science, vol. 241:58-62 (1988).
Tanaka, Ryuhei et al., "Accelerated Cell-Cycling of Hematopoietic Progenitor Cells by Growth Factors," Blood, vol. 86, No. 1:73-79 (1995).
Tsai, Li-Huei et al., "The Cdk2 Kinase is Required for the G1-to-S Transition in Mammalian Cells," Oncogene, vol. 8:1593-1602 (1993).
Hohaus, Stefan et al., "Successful Autografting Following Myeloablative Conditioning Therapy with Blood Stem Cells Mobilized by Chemotherapy Plus rhG-CSF," Experimental Hematology, vol. 21:508-514 (1993).
Kobayashi, Hirofumi et al., "Fluorescence In Situ Hybridization Mapping of Translocations and Deletions Involving the Short Arm of Human Chromosome 12 in Malignant Hematologic Diseases," Blood, vol. 84, No. 10:3473-3482 (1994).
Sui, Xingwei et al., "gp130 and c-Kit Signalings Synergize for Ex Vivo for Expansion of Human Primitive Hemopoietic Progenitor Cells," Proc. Natl. Acad. Sci., vol. 92:2859-2863 (1995).
Tedder, Thomas F. et al., "Isolation and Structure of a cDNA Encoding the B1 (CD20) Cell-surface Antigen of Human B Lymphocytes," Proc. Natl. Acad. Sci., vol. 85:208-212 (1988).
Adra, Chaker N. et al., "HT.sub.m4, A Four-Transmembrane Hematopoietic Specific Protein, Interacts With Tumor Necrosis Factor Associated Factor 2," Blood Abstract 1350, vol. 88, No. 10, suppl. 1 part 1-2:340A (1996).
Roy, A. et al., "Molecular Scanning of Human Diseases," Singapore Journal of Obstetrics and Gynaecology, vol. 26(3

Affiliated with

Also associated with

Rating

HT.sub.m4 methods of treatment and assays, agonists and antagoni does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with HT.sub.m4 methods of treatment and assays, agonists and antagoni, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and HT.sub.m4 methods of treatment and assays, agonists and antagoni will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-762798