Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1995-06-07
1999-01-12
Achutamurthy, Ponnathapura
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
514 44, 4351723, 4353201, 4352402, 530350, 536 235, 536 2372, A61K 39245, A01N 4308, C12N 1538, C07K 14005
Patent
active
058583769
ABSTRACT:
This invention relates to the use of Herpes Simplex Virus (HSV) immediate early proteins ICP47 or IE12, nucleic acid sequences coding for ICP47 and IE12, and homologous proteins and nucleic acid sequences, to inhibit presentation of viral and cellular antigens associated with major histocompatibility class I (MHC class I) proteins to CD8+T lymphocytes. This inhibition effectively increases infective persistence, which can improve the utility of viral gene therapy vectors. This invention also relates to a method of inhibiting recognition of a cell by cytotoxic T lymphocytes, comprising introducing into the cell an isolated protein of ICP47 of HSV type 1 or IE12 of HSV type 2. In addition, this invention pertains to vector elements, vectors, polypeptides and polypeptide fragments that can be utilized for these purposes.
REFERENCES:
Koelle et al. J Clin Invest vol. 91, Mar. 1993, pp. 961-968.
Coghlan. New Scientist, 25 Nov. 1995, pp. 14-15.
Posavad et al. J Virol, vol. 66, No. 11, Nov. 1992, pp. 6264-6272.
Palfreyman, et al., "Successful Use of Oligopeptides as Immunogens in the Preparation of Antisera to Immediate-Early Gene Products of Herpes Simplex Virus Type 1," The Journal of General Virology, The Society for General Microbiology, vol. 65, Part 5, pp. 865-874 (1984).
Persson, et al., "Cells that Constitutively Express the Herpes Simplex Virus Immediate-Early Protent ICP4 Allow Efficient Activation of Viral Delayed-Early Genes in trans," The Journal of General Virology, American Society for Microbiology, vol. 54, No. 2, pp. 414-421 (1985).
McGeoch, et al., "Sequence Determination and Genetic Content of the Short Unique Region in the Genome of Herpes Simplex Virus Type 1," Journal of Molecular Biology, Academic Press Inc. (London) Ltd., vol. 181, pp. 1-13 (1985).
Carter, et al., "Mapping of a Herpes Simplex Virus Type 2-Encoded Function That Affects the Susceptability of Herpes Simplex Virus-Infected Target Cells to Lysis by Herpes Simplex Virus-Specific Cytotoxic T Lymphocytes," Journal of Virology, American Society for Microbiology, vol. 49, No. 3, pp. 766-771 (1984).
Fletcher III, et al., "DNA Sequence and Genetic Organization of the Unique Short (U.sub.s) Region of the Simian Varicella Virus Genome," Virology Academic Press, Inc., vol. 193, pp. 762-773 (1993).
McGeoch, et al., "The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1," Journal of General Virology, SGM, vol. 69, pp. 1531-1547 (1988).
McGeoch, et al., "Herpes Simplex Virus" (1992).
Mavromara-Nazos, et al., "Construction and Properties of a Viable Herpes Simplex Virus 1 Recombinant Lacking Coding Sequences of the .alpha.47 Gene," Journal of Virology, American Society for Microbiology, vol. 60, No. 2 pp. 807-812 (1986).
Nishiyama, et al., "The US 9, 10, 11, and 12 Genes of Herpes Simplex Virus Type 1 Are of No Importance for Its Neurovirulence and Latency in Mice," Virology, Academic Press, Inc., vol. 194, pp. 419-423 (1993).
Whitley, "Herpes Simplex Viruses," Virology, Raven Press, Ltd., Chapter 66, pp. 1843-1887 (1990).
Marsden, et al., "Genomic Location and Lack of Phosphorylation of the HSV Immediate-Early Polypeptide IE 12," Journal of General Virology, SGM, vol. 62, pp. 17-27 (1982).
Davidson, et al., "Evolutionary Comparisons of the S Segments in the Genomes of Herpes Simplex Virus Type 1 and Varicella-Zoster Virus," Journal of General Virology, SGM, vol. 67, pp. 597-611 (1986).
Zhang, et al., "The structure of the pseudorabies virus genome at the end of the inverted repeat sequences proximal to the junction with the short unique region," Journal of General Virology, SGM, vol. 71, pp. 2433-2441 (1990).
Umene, "Conversion of a Fraction of the Unique Sequence to Part of the Inverted Repeats in the S Component of the Herpes Simplex Virus Type 1 Genome," Journal of General Virology, SGM, vol. 67, pp. 1035-1048 (1986).
Johnson, et al., "Intracellular Transport of Herpes Simplex Virus gD Occurs More Rapidly in Uninfected Cells that in Infected Cells," Journal of Virology, American Society for Microbiology, vol. 54, No. 3, pp. 682-689 (1985).
del Val, et al., "Cytomegalovirus Prevents Antigen Presentation by Blocking the Transport of Peptide-loaded Major Histocompatibility Complex Class I Molecules into the Medial-Golgi Compartment," J. Exp. Med. The Rockefeller University Press, vol. 176, pp. 729-738 (1992).
Gooding, "Virus Proteins That Counteract Host Immune Defenses," Minireview, Cell Press, vol. 71, pp. 5-7 (1992).
Mellencamp et al., "Pseudorabies Virus-Induced Suppression of Major Histovompatibility Complex Class I Antigen Expression," Journal of Virology, American Society of Microbiology, vol. 65, No. 6, pp. 3365-3368 (1991).
Johnson David C.
York Ian A.
Achutamurthy Ponnathapura
Bui Phuong T.
Johnson David C.
York Ian A.
LandOfFree
HSV proteins for inhibiting recognition by cytotoxic T lymphocyt does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with HSV proteins for inhibiting recognition by cytotoxic T lymphocyt, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and HSV proteins for inhibiting recognition by cytotoxic T lymphocyt will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1512216