Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1997-11-12
1999-10-12
Crouch, Deborah
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
4353201, 435457, 435 691, 435325, 514 44, 424 9321, C12N 1563, C12N 1500, A01N 4304, A61K 3170
Patent
active
059654414
ABSTRACT:
The present invention relates to a hybrid vector system which incorporates elements of herpesvirus and adeno-associated virus and which is capable of expressing a gene product in eukaryotic cells. The vector system of the present invention provides a means of packaging plasmid DNA into highly infectious virions which can efficiently and safely deliver large transgenes to both mitotic and postmitotic cells in a state which can be maintained for extended periods. The invention pertains to the use of this vector system in introducing and expressing gene sequences in mitotic and postmitotic cells.
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Breakefield Xandra O.
Jacoby David R.
Smith Frances I.
Crouch Deborah
Martin Jill D.
The General Hospital Coporation
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