Hst-2 muteins, pharmaceutical compositions and kits comprising s

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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530397, 530350, 530380, 435 691, 4351723, 514 2, 514 8, 514 12, A61K 3817, C07K 14435, C12N 1512

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active

056795505

ABSTRACT:
The present invention provides a polypeptide represented by the following amino acid sequence: ##STR1## wherein n is 0 or 1 and X represents Pro Ala Gly Thr Arg Ala Asn Asn Thr Leu Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly or a fragment thereof (n=0: SEQ ID NO:1, n=1: SEQ ID NO:2), a recombinant DNA coding for the polypeptide, a vector containing the recombinant DNA, the preparation of a transformant carrying the vector, and the production of the polypeptide with the transformant. The use of this peptide in pharmaceutical compositions is also provided.

REFERENCES:
Oncogene, vol. 4, No. 3, "Characterization of the HST-related FGF.6 Gene, a new member of the fibroblast growth factor gene family", pp. 335-340, Mar. 1989, Marics, I., et al.
Oncogene, vol. 7, No. 2, "Human hst-2 (FGF-6) oncogene: cDNA cloning and Characterization", pp. 303-309, 1992, Iida, S., et al.
Mol. Cell Biol., vol. 13, No. 7, "Molecular Cloning of Novel Cytokine cDNA Encoding the Ninth Member of the Fibroblast Growth Factor Family, Which has a Unique Secretion Property", pp. 4251-4259, Jul. 1993, Miyamoto, M., et al.

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