Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-08-31
2009-10-27
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S450000
Reexamination Certificate
active
07608611
ABSTRACT:
The invention provides purified 18,21-didehydro-18,21-dideoxo-18,21-dihydroxy-geldanamycin derivatives, pharmaceutically acceptable salts thereof and prodrugs thereof that are potent Hsp90 binding agents that are useful for the treatment and/or the amelioration of symptoms of cancer and other proliferative tissue disorders.
REFERENCES:
patent: 2601994 (1952-07-01), Richman
patent: 6015659 (2000-01-01), Welch et al.
patent: 6855705 (2005-02-01), Tian et al.
patent: 6872715 (2005-03-01), Santi et al.
patent: 2005/0054625 (2005-03-01), Johnson, Jr. et al.
patent: 2005/0227955 (2005-10-01), Adams et al.
patent: 2006/0019941 (2006-01-01), Adams et al.
patent: WO 94/08578 (1994-04-01), None
patent: WO 02/079167 (2002-10-01), None
patent: WO 03/066005 (2003-08-01), None
patent: WO2005063714 (2005-07-01), None
patent: WO 2005063714 (2005-07-01), None
patent: WO 2005/095347 (2005-10-01), None
patent: WO 2005095347 (2005-10-01), None
Andrus et al. Journal of Organic Chemistry, 2003, 68, 8162-8169.
Schnur er al. Journal of Medicinal Chemistry, 1995, 38, 3806-3812.
Miller et al. Cancer Research, 1994, 2724-2730.
Ariese et al. Aquatic Sciences, 2004, 66, 86-94.
Secretary, Codex Alimentarius Commission. Codex alimentarius commission, World Health Organization, Mar. 2002.
Lucken, E.A.C. The Journal of the Chemical Society, Nov. 1964, 4234-4240.
Whitesell et al. Proceedings of the National Academy of Sciences, 1994, 91, 8324-8328.
Ross. Drug Metabolism Reviews, 2004, 36 (3-4), 659-654.
Andrus et al. Journal of Organic Chemistry, 68(21), 8162-69.
Berge et al. Journal of Pharmaceutical Sciences, 1977, 66(1), 1-19.
International Search Report for related PCT application No. PCT/US05/31524.
Written Opinion for related PCT application No. PCT/US05/31524.
Extended European Search Report or Application No. EP 05810418.3, dated Feb. 16, 2009.
International Search Report for International (PCT) Patent Application No. PCT/US08/74077, mailed Nov. 19, 2008.
Written Opinion for International (PCT) Patent Application No. PCT/US08/74077, mailed Nov. 19, 2008.
Kelland, et al., “DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90”, Journal of the National Cancer Institute, Nov. 17, 1999, vol. 91, No. 22, pp. 1940-1949.
Guo, et al., “Formation of 17-Allyiamino-demethoxygeldanamycln (17-AAG) hydroquinone by NAD (P) H:quinone oxidoreductase 1: role of 17-AAG hydroquinonein heat shock protein 90 inhibition”, Cancer Res., Nov. 1, 2005, vol. 65, No. 21, pp. 10006-10015.
Dehn, at al., “Development of a new isogenic cell-xenograft system for evaluation of NAD(P)H:quinone oxidoreductase-directed antitumor quinones: evaluation of the activity of RH1.”, Clin. Cancer Res., May 1, 2004, vol. 10, No. 9, pp. 3147-3155.
Guo, et al., “The Bioreduction of a Series of Benzoquinone Ansamycins by NAD(P)H: Quinone Oxidoreductase 1 to more potent heat shock protein 90 inhibitors, the Hydroquinone Ansamycins”, Molecular Pharmacology, 2006, vol. 70, No. 4, pp. 1194-1203.
Tziveleka, et al., “Antioxidant Potential of Natural and Synthesised Polyprenylated Hydorquinones”, Bioorganic and Medical Chemistry, 2002, vol. 10, pp. 935-939.
Cysyk, et al., “Reaction of Geldanamycin and C17-Substituted Analogues with Gluthathione: Product Indentifications and Pharmacological Implications”, Chem Res. Toxicol., 2006, vol. 19, pp. 376-381.
Hu, et al., “Isolation and characterization of novel geldanamycin analogs”, Journal of Antibiotics, 2004, vol. 57, No. 7, pp. 421-428.
Guo Wenchang
Gustafson Daniel L.
Reigan Philip
Ross David
Siegel David
Jarrell Noble
Sheridan & Ross P.C.
The Regents of the University of Colorado
Wilson James O
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