Hsp72 induction and applications

Details Hsp72 induction and applications Hsp72 induction and applications

1998-02-25

2000-08-01

Jones, Dwayne C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 17, 514 19, 436 63, 436 86, 436536, 436173, 436179, A61K 3800

Patent

active

060967110

ABSTRACT:
Disclosed herein is a method for inducing Hsp72 production in a cell. The method involves contacting the cell transiently with a proteasome inhibitor in an amount sufficient to induce Hsp72 production. Preferably Hsp72 levels are induced to a level sufficient for the suppression of stress-activated kinase activity attributable, for example, to a stress-activated kinase selected from the group consisting of JNK and p38. The method has both in vitro and in vivo applications. Also disclosed is a method of the type described above is applied specifically to aged cells. Also disclosed is a method for treating pathologies associated with apoptosis and inflammation in an individual. The method involves administering to the individual a proteasome inhibitor in an amount sufficient to induce Hsp72 production. In a preferred embodiment of the therapeutic method, the individual is an aged individual. Stress-induced pathologies such as ischemia are particularly important with respect to the therapeutic aspect of the invention. Also disclosed is a method for identifying an organic compound having the ability to induce Hsp72 levels in aged cells to a level sufficient to suppress stress-activated kinase activity.

REFERENCES:
patent: 5550262 (1996-08-01), Iqbal et al.
patent: 5580854 (1996-12-01), Orlowski et al.
patent: 5614649 (1997-03-01), Iqbal et al.
patent: 5693617 (1997-12-01), Stein et al.
patent: 5942494 (1999-08-01), Ginsberg et al.
Zhou et al., The Journal of Biol. Chem. vol. 271, No. 40, pp. 24769-24775, 1996.
Rudinger, Peptide Hormones, University Park Press, pp. 1-7, 1976.
Gabai et al., J. of Biol. Chem. 272: 18033-18037 (1997).
Sistonen et al., Mol. Cell. Biol. 14: 2087-2099 (1994).
Nakai et al., Mol. Cell. Biology 15: 5268-5278 (1995).
Zhou et al., J. of Biol. Chem. 271: 24769-24775 (1996).
Morimoto et al., Stress-Inducible Cellular Responses (Feige et al., ed) eds) 77: 139-163, Birkhauser Verlag, Basel (1996).
Voellmy, R., Stress-Inducible Cellular Responses (Feige et al., ed) eds) 77: 121-137, Birkhauser Verlag, Basel (1996).
Tanabe et al., J. of Biol. Chem. 272: 15389-15395 (1997).
Simon et al., J. Clin. Invest. 95: 926-933 (1995).
Samali et al., Exp. Cell Res. 223: 163-170 (1996).
Gabai et al., FEBS Lett 375: 21-26 (1995).
Mosser et al., J. Cell Physiol. 151: 561-570 (1992).

Affiliated with

Also associated with

Rating

Hsp72 induction and applications does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hsp72 induction and applications, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hsp72 induction and applications will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-663915