Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis
Patent
1991-04-09
1992-07-21
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
Having a known elemental analysis
435171, A61K 3570, C12D 102
Patent
active
051321122
ABSTRACT:
Compounds comprising a linear .beta.1.fwdarw.6 glucan esterified by caproic acid, the number of D-glucose residues being from 7 to 40 and the number of caproic acid residues being from 2 to 30, may be be obtained by fermentation of a microorganism of the genus Aureobasidium. These compounds are designated HS-142-1. Preferred microorganism is Aureobasidium pullulans var. melanigenum KAC-2383 (FERM-BP 2407).
The compounds of the present invention exhibit excellent antagonistic activity to ANP and are capable of inhibiting the bonding of ANP to ANP receptors.
REFERENCES:
Annual Review of Pharmacological Toxology (1989).
Heparin Article, vol. 9, No. 6, Jun. 1987.
Ando Katsuhiko
Kase Hiroshi
Kawamoto Isao
Matsuda Yuzuru
Morishita Yoshikazu
Goldberg Jerome D.
Kyowa Hakko Kogyo Kabushiki Kaisha
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