HPTH-fragment-(1-37), the preparation thereof, medicaments conta

Details HPTH-fragment-(1-37), the preparation thereof, medicaments conta HPTH-fragment-(1-37), the preparation thereof, medicaments conta

1995-05-12

1998-04-28

Walsh, Stephen

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530412, 435 691, 514 2, A61K 3817, C07K 4435

Patent

active

057444447

ABSTRACT:
The invention relates to a peptide from human blood, designated as hPTH-(1-37), the structure of which was elucidated for the purpose of the diagnostic, medical and commercial utilization thereof. The isolation of a fragment hPTH-(38-84) proves the existence of the hPTH-(1-37). A removal of amino-terminal amino acids from the hPTH fragment-(1-37) reduces its biological activity. The hPTH-(1-37) circulating in the blood is identical with the synthetic reference substance hPTH-(1-37), however not with fragments such as hPTH-(1-33), hPTH-(1-34) or hPTH-(1-38). The molecule form hPTH-(1-37) has been proven by mass spectrometry (plasma desorption method). A different biological activity and differences in the three-dimensional peptide structure of the hPTH fragment-(1-37) in comparison to other hPTH fragments furnish evidence of that this fragment is the preferential natural peptide of the parathormone family which should be used for the treatment of diseases of the parathyroid, circulatory system, respiratory system, male genital organ and kidneys.

REFERENCES:
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Hesch et al., 1984, Horm. Metabol. Res., 16, 559-560.
Jacobs et al., 1985, Nature, 313, 806-810.
S. Sakakibara, "Human Parathyroid Hormone Peptide Fragment", Patent Abstracts of Japan, vol. 7, No. 39, (C-151) (1184).
J.E. Zull et al., "Characterization of Parathyroid Horome Fragments Produced by Cathepsin D", Chem. Abs., vol. 102, No. 17, Apr. 29, 1985, & J. Biol. Chem., vol. 260, No. 3, pp. 1608-1613, 1985.
S. Pillai et al., "Production of Biologically Active Fragments of Parathyroid Hormone by . . .", Chem. Abs., vol. 106, No. 5, Feb. 2, 1987, J. Biol. Chem., vol. 261, No. 32, pp. 14919-14923, 1986.

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