HPRP4s modifiers of the p53 pathway and methods of use

Details HPRP4s modifiers of the p53 pathway and methods of use HPRP4s modifiers of the p53 pathway and methods of use

2011-08-09

2011-08-09

Goddard, Laura B (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S004000

Reexamination Certificate

active

07993829

ABSTRACT:
Human hPRP4 genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of hPRP4 are provided.

REFERENCES:
patent: 6165461 (2000-12-01), Cobb et al.
Groβ et al, Nucleic Acids Research, 1997, 25:1028-1035.
Huang et al (Biochemical and Biophysical Research Communications, 2000, 271:456-463).
Colman (J of Cell Science, 1990, 97:399-409).
Summerton (Biochemica et Biophysica Acta, 1999, 1489:141-158).
Schumacher et al (Current Biology, 2001, 11:1722-1727).
Bowie et al (Science, 1990, 257:1306-1310).
Burgess et al (J of Cell Bio. 111:2129-2138, 1990).
Scott et al (Nature Genetics, 1999, 21:440-443).
Kaji et al (Molecular Carcinogenesis, 2003, 37:138-148).
Harris and Levine (Oncogene, 2005, 24:2899-2908).
Kojima et al (Journal of Biological Chemistry, 2001, 276:32247-32256).
Kojima, Tatsuya et al.: “Cloning of Human PRP4 Reveals Interaction with Clk1,” The Journal of Biological Chemistry, vol. 276, No. 34, Issue of Aug. 24, pp. 32247-32256 (2001).
Colwill et al.: “The CLK/Sry protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution,” The EMBO Journal, 1996, vol. 15, No. 2, pp. 265-275.
Gobert et al.: “Modulation of DNA Topoisomerase I activity by p53,” Biochemistry, 1996, vol. 35, pp. 5778-5786.
Papoutsopoulou et al.: “SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1,” Nucleic Acids Research, 1999, vol. 27, No. 14, pp. 2972-2980.
Nayler et al.: “Characterization and comparison of four serine-and arginine-rich (SR) protein kinases,” Biochemistry Journal, 1997, vol. 326, pp. 693-700.
T. Kojima et al.: “Homo sapiensserine/theronine-protein kinase (PRP4) mRNA, complete cds,” GenBank GI No. 14571505, Aug. 21, 2001.
T. Gross et al.: “Homo sapiensserine/theronine-protein kinase PRP4 homolog (PRP4), mRNA,” Genbank GI No. 17999534, May 16, 2002.
NCBI Annotation Project,Homo sapiensserine/theronine-protein kinase PRP4 homolog (PRP4), mRNA, GenBank GI No. 14714402, Jul. 12, 2001.
Strausberg, R. et al. “Homo sapiens, serine/theronine-protein kinase PRP4 homolog, clone IMAGE: 3943395, mRNA,” Genbank GI No. 1399461, Jul. 2, 1996.
Luetzelberger, M. et al.: “Human serine/theronine-protein kinase PRP4h (PRP4h) mRNA, complete cds,” Genbank GI No. 1399461, Jul. 2, 1996.

Affiliated with

Also associated with

Rating

HPRP4s modifiers of the p53 pathway and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with HPRP4s modifiers of the p53 pathway and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and HPRP4s modifiers of the p53 pathway and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2685018