hPDE IV-C: a novel human phosphodiesterase IV isozyme

Details hPDE IV-C: a novel human phosphodiesterase IV isozyme hPDE IV-C: a novel human phosphodiesterase IV isozyme

1995-06-07

1997-11-11

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435196, 435 691, 4352523, 4353201, 536 232, C12N 920, C12N 916, C12N 120, C12P 2106

Patent

active

056862865

ABSTRACT:
This invention relates to a novel nucleic acid sequence encoding a novel human phosphodiesterase IV (hPDE IV) isozyme. It also relates to a polypeptide encoded by such sequence.
This invention also relates to an assay method for detecting the presence of such novel isozyme in human cells, and to a method of identifying compounds or other substances that inhibit or modify the activity of such isozyme.

REFERENCES:
patent: 5501969 (1996-03-01), Hastings et al.
patent: 5504003 (1996-04-01), Li et al.
patent: 5506133 (1996-04-01), Yu et al.
Bolger et al. Molecular and Cellular Biology 13(10):6558-6571, Oct. 1, 1993.
Obernolte et al. Gene, 129(2):239-247, Jul. 30, 1993.
Swinnen et al. Proc. Natl. Acad. Sci USA 86:8197-8201, Nov. 1, 1989.

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