House dust mite allergen, Der p VII, and uses thereof

Details House dust mite allergen, Der p VII, and uses thereof House dust mite allergen, Der p VII, and uses thereof

1995-06-05

2000-06-20

Duffy, Patricia A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

514 2, 514 16, 530328, 530350, A61K 3935, C07K 100

Patent

active

060775173

ABSTRACT:
A novel protein allergen Der p VII of Dennatophagoides pteronyssinus is described. A cDNA clone encoding Der p VII was isolated from a .lambda.gt11 library of D. pteronyssinus cDNA. The nucleic acid sequence of der p VII encodes a 198 residue mature processed protein having a predicted molecular weight of 22,177 daltons. Der p VII protein may be used as the active ingredient in therapeutic composition for the treatment of sensitivity to house dust mites. The protein may also be used in methods of diagnosing such sensitivity.

REFERENCES:
patent: 4879213 (1989-11-01), Fox
Baldo et al. (1989) "Toward a Definition of the `Complete` Spectrum and Rank Order of Importance of the Allergens from the House Dust Mite: Dermatophagoides pteronyssinus" Adv. BioScience 74: 13-31.
Bengtsson et al. (1986) "Detection of Allergens in Mould and Mite Preparations by a Nitrocellulose Electroblotting Technique" Int. Arch. Appl. Immun. 80: 383-390.
Chapman et al. (1980) "Purification and Characterization of the Major Allergen from Dermatophagoides Pteronyssinus-Antigen P1" Journal of Immunology 125(2): 587-592.
Chiba et al. (1990) "Experimental Cedar Pollinosis in Rhesus Monkeys" Int. Arch. Allergy Appl. Immunol. 93: 83-88.
Chua et al. (1990) "Expression of Dermatophagoides Pteronyssinus Allergen, Der pll, in Escherichia coli and the Binding Studies with Human IgE" Int. Arch. Allergy Appl. Immunol. 91: 124-129.
Ford et al. (1990) "The Spectrum of Low Molecular Weight House Dust Mite (Dermatophagoides Pteronyssinus) Allergens with Emphasis on Der p II" Clinical and Experimental Allergy 20(1): 27-31.
Greene et al. (1990) "Antigenic Analysis of Group i House Dust Mite Allergens Using Random Fragments of Der p i Expressed by Recombinant DNA Libraries" Int. Arch. Appl. Allergy Immunol. 92: 30-38.
Greene et al. (1992) "IgE Binding Structures of the Major House Dust Mite Allergen Der P I" Molecular Immunology 29(2): 25777-262.
King et al. (1976) "Chemical and Biological Properties of Some Atopic Allergens" Advances in Immunology 23: 77-105.
Kohmoto et al. (1991) "Activation of the Kallikren-Kinn System in Human Plasma by a Scrine Protease from Mites" Journal Clin. Biochem. Nutr. 10: 15-20.
Lind et al. (1983) "Identification of Allergens in Dermatophagoides pteronyssinus Mite Body Extract by Crossed Radioimmunoelectrophoresis with Two Different Rabbit Antibody Pools" Scand. J. Immunol. 17: 263-273.
Lind (1985) "Purification and Partial Characterization of Two Major Allergens from the House Dust Mite Dermatophagoides Pteronyssinus" Journal of Allergy and Clinical Immunology 76(5): 753-761.
Stewart et al. (1992) "The Group III Allergen from the House Dust Mite Dermatophagoides Pteronyssinus is a Trypsin-like Enzym" Immunology 75: 29-35.
Stewart et al. (1988) "Standardization of Rye-Grass Pollen (lolium perenne) Extract" Int. Arch. Allergy Appl. Immun. 86: 9-18.
Thomas et al. (1988) "Cloning and Expression of DNA Coding for the Major House Dust Mite Allergen Der p l in Escherichia coli" Int. Arch. Allergy Appl. Immun. 85: 127-129.
Tovey et al. (1989) "The Cloning of a Mite (Dermatophagoides Pteronyssinus) Recombinant Protein that Shares IgE--Binding Determinants with a 14-15KD Component of Mite Extracts" Advances in Biosciences 74: 33-43.
Tovey et al. (1987) "Comparison by Electroblotting of IgE-binding Components in Extracts of House Dust Mite Bodies and Spent Mite Culture" Journal of Allergy and Clinical Immunology 79(1): 93-102.
Van der Zee et al. (1988) "Skin Tests and Histamine Release with P1-depleted Dermatophagoides Pteronyssinus Body Extracts and Purified P1" Journal of Allergy and Clinical Immunology 81(5): 884-896.
Yuuki et al. (1991) "Cloning and Expression of cDNA Coding for the Major House Dust Mite Allergen Derf II in Escherichia coli" Agric. Biol. Chem. 55(5): 1233-1238.
Critical Synergy: The Biotechnology Industry and Intellectual Property Protection, Presentation of the Intellectual Property Committee of the Biotechnology Industry Organization at the Oct. 17, 1994, Hearing of the U.S. Patent and Trademark Office, San Diego, CA, published by the Biotechnology Industry Organization, Washington, D.C. pp. 75 and 100-107.
Shen, H. et al., "Molecular cloning of a house dust mite allergen with common antibody binding specificities with multiple components in mite extracts", Clinical and Experimental Allergy, vol. 23, pp. 934-940 (1993).
Burgess et al. J. Cell Biology III:2129-2137 1990.
Lozar et al. Mol. and Cellular Biology 8(3):1247-52 1988.
Kumar et al. PNAS 87:1337-1341 1990.
Bowie et al. Science 247:1306-1310 1990.
Stewart et al. Int. Arch Allergy App. Immunology 69(3):224-230 1982.
Stewart et al. Aust. J. Exp. Biol. Med. Sci 58(3):259-74 1980.
Abe et al. Allergy 42(5):352-358 1977.
Hoyne et al. Immunology 78(1):65-73 Jan. 1993
Roitt et al. Immunology Gower Medical Publishing Company (New York) 1985 p. 19.2.
Terr A.I. "Allergic Diseases" in Basic Clinical Immunology 6th Edition, Stites et al. Eds Appleton and Lang (Norwalk CN) 1987 pp. 435 and 442.

Affiliated with

Also associated with

Rating

House dust mite allergen, Der p VII, and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with House dust mite allergen, Der p VII, and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and House dust mite allergen, Der p VII, and uses thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1849890