Hot-water extracts of neem bark

Details Hot-water extracts of neem bark Hot-water extracts of neem bark

1983-10-13

1985-08-27

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

A61K 3578

Patent

active

045377740

ABSTRACT:
Hot-water extracts of the neem bark produced by treating the bark of neem with water at a temperature from 0.degree. to 40.degree. C. and subjecting the residue from said pre-extraction treatment to extraction treatment with hot water. Purification of the extract thus produced by means of alcohol precipitation or dialysis gives products of a higher purity. Moreover, treatments prior to the pre-extraction treatment with water at 0.degree.-40.degree. C. with a non-polar organic solvent having a dielectric constant of 10 or lower and a polar organic solvent having a dielectric constant from 15 to 35 yields neem extracts of a further higher purity. The hot-water extracts of the neem bark according to the present invention possess activity against mouse L-5178Y cells and transplanted sarcoma 180 tumors.

REFERENCES:
Cancer Research, 27:6-8, 11 and 105, 1967.
Tetrahedron, 10:45-54, 1960, Pergaman Press Ltd., Ireland.

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