Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-02-21
2006-02-21
Tsang, Cecilia J. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C536S119000
Reexamination Certificate
active
07001886
ABSTRACT:
The invention pertains to a method for preparing diphenhydramine tannate by reacting diphenhydramine free base at a temperature of about 75 to about 150° C. with tannic acid neat or as an aqueous slurry containing up to about 20 wt. % water. The diphenhydramine free base may be obtained by reacting a commercially available diphenhydramine salt such as diphenhydramine maleate with a base such as aqueous sodium hydroxide. The resultant diphenhydramine tannate has extended release properties and is useful in pharmaceutical compositions as an antihistamine for human beings.
REFERENCES:
patent: 5663415 (1997-09-01), Chopdekar et al.
patent: 6268012 (2001-07-01), Sikora et al.
patent: 6287597 (2001-09-01), Gordziel
patent: 6509492 (2003-01-01), Venkataraman
Achari Raja G.
Chopdekar Vilas M.
Redkar Sham N.
Schleck James R.
Jame Fine Chemicals, Inc.
Matalon Jack
Oh Taylor Victor
Tsang Cecilia J.
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