Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1996-11-18
1999-10-12
Stanton, Brian R.
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
4353201, 435325, 435440, 536 235, C12N 1500, C12N 500, C07H 2104
Patent
active
059654392
ABSTRACT:
Nucleic and amino acid sequences for a novel cell surface transmembrane glycoprotein designated ClqR.sub.P are taught. A method by which the nucleic acid sequence encoding ClqR.sub.P may be used to modulate the role of the immune system is also described. Transgenic animals created with heterologous DNA sequence encoding ClqR.sub.P are described as well as antibodies directed against the ClqR.sub.P protein. A method of hybridization for ClqR.sub.P nucleic acid using oligonucleotide probes based on the ClqR.sub.P nucleic acid sequence and methods for detecting a hybrid probe:target ClqR.sub.P duplex are also taught including a kit for such detection.
REFERENCES:
patent: 4946788 (1990-08-01), Delespesse
patent: 5552282 (1996-09-01), Caskey et al.
Tenner et al., "Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 Mr component of the C1q receptor", Immunity, vol. 3, No. 4, Oct. 1995, pp. 485-493.
Crockard et al., "Increased expression of C1q receptors on neutrophils from inflammatory joint fluids", Immunology Letters, vol. 36, 1993, pp. 195-202.
Ghebrehiwet et al., "Isolation, cDNA cloning and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1qa", The Journal of Expreimental Medicine, vol. 179, No. 6, Jun. 1, 1994, pp. 1809-182
Nepomuceno et al., "cDNA cloning and primary structure analysis of C1qRp, the human C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro", Immunity, vol. 6, No. 2, Feb. 1997, pp. 119-129.
Crystal, R. G. Transfer of genes to humans: early lessons and obstacles to success. Science, vol. 270, pp. 404-410, Oct. 20, 1995.
Orkin et al. Report and recommendations of the panel to assess the NIH investment in research on gene therapy. Distrubuted by the National Institutes of Health, Bethesda, MD, Dec. 7, 1995.
Turner, "Mannose-binding lectin: the pluripotent molecule of the innate immune system", Immunology Today, vol. 17, No. 11, pp. 532-540, (1996).
Randi, "Itatel Group: Italian telecom for the next century", Scientific American, 262:40, (1990).
Jaenisch, "Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus", Proc. Nat. Acad. Sci. USA, vol 73, No. 4, pp. 1260-1264, (1976).
Furth et al., "Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter", Proc. Natl. Acad. Sci. USA, 91:9302-9306, (1994).
Li et al., "Targeted Mutation of the DNA Methyltransferase Gene Results in Embryonic Lethality", Cell, 69:915-926, (1992).
Stewart et al., "Expression of retroviral vectors in transgenic mice obtained by embryo infection", EMBO Jrnl, Vo. 6, No. 2, pp. 383-388, (1987).
Rosenberg et al., "Vectors for selective expression of cloned DNAs by T7 RNA polymerase", Gene, 56:125-135, (1987).
Gossler et al., "Transgenesis by means of blastocyst-derived embryonic stem cell lines", Proc. Natl. Acad. Sci. USA, 33:9065-9069, (1986).
Cheng et al. "Nonsense Condons Can Reduce the Abundance of Nuclear mRNA without Affecting the Abundance of Pre-mRNA or the Half-Life of Cytoplasmic mRNA", Mol. and Cell Biol., vol. 13, No. 3, pp. 1892-1902, (1993).
Hanson et al., "Analysis of Biological Selections for High Efficiency Gene Targeting", Mol. and Cell Biol., vol. 15, No. 1, pp. 45-51 (1995).
Deng et al., "Reexamination of Gene Targeting Frequency as a Function of the Extent of Homology between the Targeting Vector and the Target Locus", Mol. and Cell Biol., Vo. 12, No. 8, pp. 3365-3371 (1992).
Urlaub et al., "Nonsense Mutations in the Dihydrofolate Reductase Gene Affect RNA Processing", Mol. and Cell Biol., vol. 9, No. 7, (1989).
Daar, et al. "Premature Translation Termination Mediates Triosephosphate Isomerase mRNA Degradation", Mol. and Cell Biol., vol. 8, No. 2, pp. 802-813, (1988).
Wolff et al., "Direct Gene Transfer into Mouse Muscle in Vivo", Science, 247:1465, (1990).
Wang et al., "Mice lacking ornithine-.delta.-amino transferase have paradoxical neonatal hypoornithinaemia and retinal degeneration", Nature Genetics, 11:185, (1995).
Andrikopoulos, et al., "Targeted mutation in the col5a2 gene reveals regulatory role for type V collagen during matrix assembly", Nature Genetics, 9:31-36, (1995).
Bradley et al., "Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines", Nature, 309:255-256, (1984).
Evans et al., "Establishment in culture of pluripotential cells from mouse embryos", Nature, 292:154-156, (1981).
Jahner et al., "De novo methylation and expression of retroviral genomes during mouse embryogenesis", Nature 298:623-626, (1982).
Kohler et al., "Continuous cultures of fused cells secreting antibody of predefined specificity", Nature 256:495-497 (1975).
Ono et al., "Plasmid DNAs directly injected into mouse brain with lipofectin can be incorporated and expressed by brain cells", Neuroscience Letters, 117:259-263, (1990).
Wu et al., "Receptor-mediated Gene Delivery and Expression in Vivo", Jrnl. Biol. Chem., vol. 263, No. 29, pp. 14621-14624, (1988).
Lee et al., "Proliferin Secreted by Cultured Cells Binds to Mannose 6-Phosphate Receptors", Jrnl. Biol. Chem., vol. 263, No. 7, pp. 3521-3527, (1988).
Fraley et al., "New generation liposomes: the engineering of an efficient vehicle for intracellular delivery of nucleic acids", TIBS, pp. 77-80, (Mar. 1981).
Felgner et al., "Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure", Proc. Natl. Acad. Sci. USA, 84:7413-747, (1987).
Marcus-Sekura, "Techniques for Using Antisense Oligodeoxyribonucleotides to Study Gene Expression", Analytical Biochemstry, 172:289-295, (1988).
Straubinger et al., "Liposomes as Carriers for Intracellular Delivery of Nucleic Acids", Methods in Enzym. 101:512, (1983).
Cross et al., "Pretreatment with Recombinant Murine Tumor Necrosis Factor .alpha./Cachetin and Murine Interleukin 1 .alpha. Protects Mice from Lethal Bacterial Infection", Jrnl. Exp. Med., 169:2021-2027, (1989).
Bohnsack et al., "Connective Tissue Proteins and Phagocytic Cell Function", Jrnl. Exp. Med., 161:912-923 (1985).
Argraves et al., "Amino Acid Sequence of the Human Fibronectin Receptor", Jrn. Cell Biol., 105:1183-1190, (1987).
Tenner et al., "Purification and Radiolabeling of Human C1q.sup.1 ", Jrnl. Immunol., vol. 127, No. 2, pp. 648-653, (1981).
Gu et al., "Deletion of a DNA Polymerase .beta. Gene Segment in T Cells Using Cell Type-Specific Gene Targeting", Science, 265:103-106 (1994).
Jaenisch, "Transgenic Animals", Science, 240:1468-1474, (1988).
Stothers, "Periodicity of the Earth's magnetic reversals", Nature, 322:444-446 (1986).
Ezekowitz, et al., "Molecular Characterization of the Human Macrophage Mannose Receptor: Demonstration of Multiple Carbohydrate Recognition-like Domains and Phagocytosis of Yeasts in COS-1 Cells", J. Exp. Med., 172:1785-1794, (1990).
Brinster et al., "Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs", Proc. Natl. Acad. Sci. USA., 82:4438-4442 (1985).
Jahner et al., "Insertion of the bacterial gpt gene into the germ line of mice by retroviral infection", Proc. Natl. Acad. Sci. USA, 82:6927-6931 (1985).
van der Putten et al., "Efficient insertion of genes into the mouse germ line via retroviral vectors", Proc. Natl. Acad. Sci. USA, 82:6148-6152 (1985).
Lammli, "Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4", Nature, 227:680-685 (1970).
Sauer et al., "Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1", Proc. Natl. Acad. Sci. USA, 85:5166-5170 (1988).
Towbin et al., "Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications", Proc. Natl. Acad. Sci. USA, 76:4350-4345 (1979).
Bobak et al., "C1q acts synergistically with phorbol dibutyrate to activate CR1-mediated phagocytosis by human mononuclear phagocytes", Eur. J. Immunol. 18:2001-2007 (1988).
Stacey et al., "Use of Double-Replacement Gene Targeting To Replace the Murine .alpha.-Lactalbumin Gene with Its Human Counterpart in Embryonic Stem Cells and Mice"
Nepomuceno Ronald R.
Tenner Andrea J.
Clark Deborah J. R.
Stanton Brian R.
The Regents of the University of California
LandOfFree
Host defense enhancement does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Host defense enhancement, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Host defense enhancement will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-651709