Host defense enhancement

Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...

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4353201, 435325, 435440, 536 235, C12N 1500, C12N 500, C07H 2104

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059654392

ABSTRACT:
Nucleic and amino acid sequences for a novel cell surface transmembrane glycoprotein designated ClqR.sub.P are taught. A method by which the nucleic acid sequence encoding ClqR.sub.P may be used to modulate the role of the immune system is also described. Transgenic animals created with heterologous DNA sequence encoding ClqR.sub.P are described as well as antibodies directed against the ClqR.sub.P protein. A method of hybridization for ClqR.sub.P nucleic acid using oligonucleotide probes based on the ClqR.sub.P nucleic acid sequence and methods for detecting a hybrid probe:target ClqR.sub.P duplex are also taught including a kit for such detection.

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