Host cells comprising Streptomyces clavuligerus chromosomal...

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

Reexamination Certificate

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C435S252330, C435S252350, C435S254110, C435S254500, C435S069100, C536S023200

Reexamination Certificate

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06964865

ABSTRACT:
DNA sequences obtained fromS. clavuligerusATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed.The DNA comprises one or more genes coding for one or more enzymes involved in the biosynthesis of penicillin and cephalosporin β-lactams and such enzymes are expressed by hosts into which the recombinant vectors are transformed.The DNA and the enzymes encoded thereby have utility in the preparation of penicillins and cephalosporins, both known and novel, possessing pharmacological, especially antimicrobial, activity.

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