Host cells comprising cDNA corresponding to the antigenome...

Details Host cells comprising cDNA corresponding to the antigenome... Host cells comprising cDNA corresponding to the antigenome...

2008-07-22

2008-07-22

Falk, Anne-Marie (Department: 1632)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S320100, C424S093100, C424S093200

Reexamination Certificate

active

07402429

ABSTRACT:
The present invention relates, in general, to a methodology for the generation or nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a model for other representatives of the Mononegavirales, in particular the family Paramyxoviridae.

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