Host cell line LVIP2.0Zc, useful in assays to identify ligands a

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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4353201, 435 721, C12N 510

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active

055321577

ABSTRACT:
The present invention relates, in general, to a method of identifying ligands and antagonists of ligands. In particular, the present invention relates to a method of identifying ligands and antagonists of ligands which bind to cloned G.sub.s - or G.sub.i -coupled receptors. The present invention also relates to a cell that comprises a recombinant cyclic AMP sensitive reporter construct.

REFERENCES:
patent: 5126251 (1992-06-01), Moss et al.
Konig et al. (1991) Mol Cell Neurosci vol. 2 (4). pp. 331-337.

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