Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-12-08
1999-10-19
Ketter, James
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 694, 435 6951, 435 696, 435189, 435198, 435212, 435484, C12P 2102
Patent
active
059687746
ABSTRACT:
The present invention relates to novel host cells and to methods of producing proteins. More specifically the invention relates to a host cell useful for the expression of heterologous proteins, which host cell has been genetically modified in order to express significantly reduced levels of a metalloprotease. Moreover the invention relates to a method of producing a heterologous protein, which method comprises cultivating the host cell in a suitable growth medium, followed by recovery of the desired protein.
REFERENCES:
Tatsumi et al., "Cloning And Expression In Yeast Of A cDNA Clone Encoding Aspergillus oryzae Neutral Protease II, A Unique Metalloprotease", Mol Gen Genet, 1991, 228: pp. 97-103.
Ketter James
Lambiris, Esq. Elias J.
Novo Nordisk A S
Zelson Esq. Steve T.
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