Horseshoe crab amebocyte lysate factor G activation inhibitor

Details Horseshoe crab amebocyte lysate factor G activation inhibitor Horseshoe crab amebocyte lysate factor G activation inhibitor

1995-10-13

1997-06-24

Kight, John

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 18, 435 34, 5361231, 53612312, C12Q 137, C12Q 134, C07H 306, C08B 3718

Patent

active

056416431

ABSTRACT:
This invention relates to a horseshoe crab amebocyte lysate factor G activation inhibitor comprising as an active ingredient a polyglycoside containing at least one poly-(1.fwdarw.3)-.beta.-D-glucoside structure portion consisting of 2 to 370 (1.fwdarw.3)-.beta.-D-glucoside structural units of the following formula ##STR1## which are continuously bound to one another. This inhibitor is useful for inhibiting the activation of factor G which may exist in horseshoe crab amebocyte lysate used in the Limulus test.

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Bacterial Endotoxins: Structure, Biomedical Significance, and Detection with Limulus Amebocyte Lysate Test, pp. 53-64; Biomedical Characterization of Limulus Clotting Factors and Inhibitors which interact with Bacterial Endotoxins, 1985, Alan R. Liss, Inc., Morita et al.
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