Hormone-sensitive lipase mediated male infertility

Details Hormone-sensitive lipase mediated male infertility Hormone-sensitive lipase mediated male infertility

2006-05-23

2006-05-23

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

C435S069200, C435S198000, C536S023200

Reexamination Certificate

active

07049092

ABSTRACT:
In various aspects, the invention provides pharmacologic and genomic methods of inhibiting fertility in a male animal, such as human male contraception, involving the manipulation of the activity of hormone-sensitive lipase, including inhibiting the activity of a hormone-sensitive lipase in the animal. In another aspect, the invention discloses the use of hormone-sensitive lipase as a target in screening assays that may be used to identify compounds that modulate male fertility. In another aspect, the present invention identifies a condition of male infertility caused by hormone-sensitive lipase deficiency.

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