Hormone replacement therapy drug formulations for topical applic

Details Hormone replacement therapy drug formulations for topical applic Hormone replacement therapy drug formulations for topical applic

1997-10-16

1999-10-19

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514467, 514182, 424448, 424449, A61K 3156

Patent

active

059689196

ABSTRACT:
Topical alcoholic or aqueous alcoholic gels containing testosterone, progesterone, estradiol or other hormones have enhanced penetration through skin by including in the formulation 2-n-nonyl-1,3-dioxolane or other hydrocarbyl derivative of 1,3-dioxolane or 1,3-dioxane or acetal, as skin penetration enhancing compound.

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Samour, et al., Proc. Int. Symp. Control. Rel. Bioact. Mater. 16:183-184 (1989).
Marty, et al., Proc. Int. Symp. Control. Rel. Bioact. Mater. 16:179-180 (1989).
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Michniak, et al., Drug Delivery 2:117-122 (1995).
Marty, et al., Abstract of Paper Presented at American Assoc. of Pharmaceutical Scientists, Washington, D.C., Mar. 26-28, 1990.

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