Hormone replacement formulation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Reexamination Certificate

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Details

C514S171000, C514S179000, C514S182000

Reexamination Certificate

active

06911438

ABSTRACT:
The formulation comprises a combination of three estrogens and selected amount of other elements. The three estrogens include 2-hydroxyestrone, 17-beta estradiol, and estriol. The amount of 17-beta estradiol is substantially less than the amounts of 2-hydroxyestrone and estriol, both which are approximately equal in amount. The amounts of pyridoxine, folic acid, selenium and cobalt are therapeutically effective amounts.

REFERENCES:
patent: 6174665 (2001-01-01), Dullien
patent: 6329358 (2001-12-01), Cavazza
patent: 6479545 (2002-11-01), Levinson et al.
patent: 403115222 (1991-05-01), None
patent: 403115222 (1991-05-01), None
patent: WO99/53910 (1999-10-01), None
JP 403115222, Derwent Abstract, Derwent -ACC-No. 1991-188847.
“Textbook of Organic Medicinal and Pharmaceutical Chemistry”, Dwight S. Fullerton et al., 9th edition (Jan. 1991) Lippincott Williams & Wilkins Publishers, p. 691, 694, 698.
Schubert et al., “Hormonsubstitution in der Postmenopause-Auswirkungen auf Spurenelemente und ox. LDL-Antikorper (Substituttion of hormones in the post-menopause effects on trace elements and ox. LDL antibodies)”, 1996, Mengen- Spurenelem, p. 57-63.
CAPLUS abstract, Accession No. 1997:421726, 1996, Schubert et al., p. 1.

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