Hormonally up-regulated, neu-tumor-associated kinase

Details Hormonally up-regulated, neu-tumor-associated kinase Hormonally up-regulated, neu-tumor-associated kinase

2006-10-10

2006-10-10

Siew, Jeffrey (Department: 1642)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023200, C536S023500

Reexamination Certificate

active

07119185

ABSTRACT:
This invention relates generally to a novel serine/threonine protein kinase, specifically to hormonally up-regulated, neu-tumor-associated kinase (HUNK); and to the nucleotide sequence encoding it. The kinase is temporally expressed during postnatal mammary development in a spatially heterogeneous manner in certain subsets of cells, and overexpressed in a subset of primary breast cancers. The invention further relates to an analysis of a correlation between carcinogenesis and postnatal development, particularly mammary development, especially associated with parity; to methods of using the kinase, or gene encoding it, as markers, prognostic tools, screening tools and therapies, in vitro and in vivo, that are based upon that correlation; and to the regulation of pregnancy-induced changes in the mammary tissue that occur in response to estrogen and progesterone.

REFERENCES:
Gardner et al. (Genomics 2000, 64, 46-59).
NCBI database for nucleotides (Accession No.: AF055919, Apr. 28, 1999, See attached comparison).
Alberts et al. (Molecular Biology of the Cell, see attached).
Naylor, L.H. (Biochemical Pharmacology 1999, 58:749-757).
Aasheim, H.C., Terstappen, L. W., and Logtenberg, T. “Regulated expression of the Eph-related receptor tyrosine kinase Hek11 in early human B lymphopoiesis.”Blood90: 3613-3622 (1997).
Adams, R. H., Wilkinson, G. A., Weiss, C., Diella, F., Gale, N. W., Deutsch, U., Risau, W., and Klein, R. “Roles of ephrinB ligands and EphB receptors in cardiovascular development: De-marcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.”Genes Dev.13: 295-306 (1999).
Adnane, J., Gaudray, P., Dionne, C. A., Crumley, G., Jaye, M., Schlessinger, J., Jeanteur, P., Birnbaum, D., and Theillet, C. “BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers,”Oncogene6:659-663 (1991).
Alderson, A., Sabelli, P., Dickinson, J., Cole, D., Richardson, M., Kreis, M., Shewry, P., and Halford, N. “Complementation of snf1, a mutation affecting global regulation of carbon metabolism in yeast, by a plant protein kinase cDNA,”Proc. Natl. Acad. Sci. USA88: 8602-8605 (1991).
Andres, A.-C., Zuercher, G., Djonov, V., Flueck, M., and Ziemiecki, A. “Protein tyrosine kinase expression during the estrous cycle and carcinogenesis of the mammary gland.”Int. J. Cancer63: 288-296 (1995).
Becker, W., Heukelbach, J., Kentrup, H., and Joost, H. G. “Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a sub-family of serine/threonine kinases.”Eur. J. Biochem.235: 736-743 (1996).
Bergemann, A. D., Zhang, L., Chiang, M. K., Brambilla, R., Klein, R., and Flanagan, J. G. “Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube,”Oncogene16:471-480 (1998).
Bessone, S., Vidal, F., Le Bouc, Y., Epelbaum, J., Bluet-Pajot, M. T. and Darmon, M., “EMK protein kinase-null mice: dwarfism and hypofertility associated with alternations in the somatotrope and prolactin pathways.”Dev. Biol.214: 87-101 (1999).
Betzl, G., Brem, G. and Weidle, U. H. “Epigenetic modification of transgenes under the control of the mouse mammary tumor virus LTR: tissue-dependent influence on transcription of the transgenes,”Biol. Chem.377: 771-719 (1996).
Bishop, D. F., Calhoun, D. H., Bernstein, H. S., Hantzopoulos, P., Quinn, M., and Desnick, R. J. “Human alpha-galactosidase A: Nucleotide sequence of a cDNA clone encoding the mature enzyme.”Proc. Natl. Acad. Sci. USA83: 4859-4863 (1986).
Bocchinfuso, W.P. and Korach, K.S. “Mammary gland development and tumorigenesis in estrogen receptor knockout mice.”J. Mamm. Gland Biol. Neoplasia2: 323-334 (1997).
Bohm, H., Brinkmann, V., Drab, M., Henske, A., and Kurzchalia, T.V. “Mammalian homologues ofC. elegansPAR-1 are asymmetrically localized in epithelial cells and may influence their polarity.”Curr. Biol.7: 603-606 (1997).
Brinkley, P. M., Class, K., Bolen, J. B., and Penhallow, R. C. “Structure and developmental regulation of the murine ctk gene.”Gene163: 179-184 (1995).
Buhler, T. A., Dale, T. C., Kieback, C., Humphreys, R. C. and Rosen, J. M. “Localization and quantification of Wnt-2 gene expression in mouse mammary development.”Dev. Biol.155: 87-96 (1993).
Cance, W. G. Craven, R. J., Weiner, T. M., and Liu, E. T. “Novel protein kinases expressed in human breast cancer.”Int. J. Cancer54: 571-577 (1993).
Cardiff, R. D., and Muller, W. J. “Transgenic mouse models of mammary tumorigenesis.”Cancer Surv.16: 97-113 (1993).
Cardiff, R. D., Sinn, E., Muller, W., and Leder, P. “Transgenic oncogene mice. Tumor phenotype predicts genotype.”Am. J. Pathol.139: 495-501 (1991).
Carling, D., Aguan, K., Woods, A., Verhoeven, A. J., Beri, R. K., Brennan, C. H., Sidebottom, C., Davison, M. D., and Scott, J. “Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism.”J. Biol. Chem.269: 11442-11448 (1994).
Carlson, M., Osmond, B., and Botstein, D. “Mutants of yeast defective in sucrose utilization.”Genetics98: 25-40 (1981).
Celenza, J. L., Eng, F. J., and Carlson, M. “Molecular analysis f the SNF4 gene ofSaccharomyces cerevisiae:Evidence for physical association of the SNF4 protein with the SNF1 protein kinase.”Mol. Cell. Biol.9: 5045-5054 (1989).
Cho, R. J., Campbell, M. J., Winzeler, E. A., Steinmetz, L., Conway, A., Wodicka, L., Wolfsberg, T. G., Gabrielian, A. E., Landsman, D., Lockhart, D. J., and Davis, R. W. “A genome-wide transcriptional analysis of the mitotic cell cycle.”Mol. Cell2: 65-73 (1998).
Chodosh, L. A., D'Cruz, C. M., Gardner, H. P., Ha, S. I., Marquis, S. T., Rajan, J. V., Stairs, D. B., Wang, J. Y., and Wang, M. “Mammary gland development, reproductive history, and breast cancer risk.”Cancer Res.59: 1765-1771S (1999).
Chodosh, L. A., Gardner, H. P., Rajan, J. V., Stairs, D. B., Marquis, S. T., and Leder, P. A. “Protein kinase expression during murine mammary development.”Dev. Biol.219: 259-276, (2000).
Ciriacy, M. “Isolation and characterization of yeast mutants defective in intermediary carbon metabolism and in carbon catabolite repression.”Mol. Gen. Genet.154: 213-220 (1977).
Copeland, N. G., and Jenkins, N. A. “Development and applications of a molecular genetic linkage map of the mouse genome.”Trends Genet.7: 113-118 (1991).
Delabar, J. M., Theophile D., Rahmani, Z., Chettah, Z., Blouin, J. L., Prieur, M,, Noel, B., and Sinet, P. M., “Molecular mapping of twenty-four features of Down syndrome on chromosome 21.”Eur. J. Hum. Genet.1: 114-124 (1993).
Di Fiore, P., Pierce, J. H., Fleming, T. P., Hazan, R., Ullrich, A., King, C. R., Schlessinger, J. and Aaronson, S. A. “Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells.”Cell51: 1063-1070 (1990).
Drewes, G., Ebneth, A., Preuss, U., Mandelkow, E. M., and Man-delkow, E. “MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger micro-tubule disruption.”Cell89: 297-308 (1997).
Dymecki, S. M., Niederhuber, J. E., and Desiderio, S. V. “Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells.”Science247: 332-336 (1990).
Elson, A., and Leder, P. “Protein-tyrosine phosphatase epsilon. An isoform specifically expressed in mouse mammary tumors initiated by v-Ha-ras or neu.”J. Biol. Chem.270: 2611-26122 (1995).
Fan, C. M., Kuwana, E., Bulfone, A., Fletcher, C. F., Copeland, N. G.,Jenkins N. A., Crews, S., Martinez, S., Puelles, L., Rubenstein, L. R., and Tessier-Lavigne, M. “Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles

Affiliated with

Also associated with

Rating

Hormonally up-regulated, neu-tumor-associated kinase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Hormonally up-regulated, neu-tumor-associated kinase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Hormonally up-regulated, neu-tumor-associated kinase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3658845