Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1996-09-16
1999-06-08
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514178, 514182, 514859, 514864, A61K 3156
Patent
active
059104937
ABSTRACT:
The pharmaceutical composition, especially for treating skin with seborrhea, Acne vulgaris and androgonically conditioned alopecia, contains a hormonal agent including the gestogen, dienogest, or a combination of dienogest and an estrogen, as active ingredient. Methods for treatment of this type of skin condition include topical application of the composition including the dienogest which results in an outstanding sebosuppression, a drastic reduction of androstandiol glucuronide and a moderate competitive blockage of androgen receptor sites. Galenic formulations are described which limit and/or prevent the permeation of the active ingredient through the skin. The pharmaceutical preparation including the dienogest and conventional dermatologically acceptable carrier and auxiliary substances in the described galenic formulation advantageously provides a drastic reduction in androstandiol glucuronide and moderate androgen receptor blockage without passing through the skin barrier so that systemic effects including side reactions are substantially prevented.
REFERENCES:
"Purification of Androgen Receptors in Human Sebocytes and Hair", by M. Sawaya, The Society for Investigative Dermatology, Inc.
"Localization of androgen receptors in human skin by immunohistochemistry: implications for the hormonal regulation of hair growth, sebaceous glands and sweat glands", by R. Choudhry et al, in J. Endocr. 133, pp. 467 475, 1992.
Phytoestrogens--A Short Reveiw, by David C. Knight, John A. Eden, Royal Hospital for Women.
A Review of the Clinical Effects of Phytoestrogens, by David Knight, FRACOG and John A. Eden, FRACOG., vol. 87, No. 5, Part 2, May 1996.
Dittgen Michael
Golbs Siegfried
Graser Thomas
Luderschmidt Christoph
Oettel Michael
Jenapharm GmbH
Schenkman Leonard
Striker Michael J.
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