Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1993-04-30
1995-06-27
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435214, 514 12, C12N 948, C12N 974, A61K 3800
Patent
active
054279372
ABSTRACT:
A soluble anticoagulant protein isolated and purified from Ancylostoma hookworms markedly prolongs both the prothrombin time and partial thromboplastin time in clotting assays. The protein has an apparent molecular weight of about 6500 daltons and exhibits amino acid sequence homology to the Kunitz-type serine protease inhibitor family. Chromogenic peptide substrate and clotting time assays indicate that the protein inhibits extrinsic pathway clotting factor VIIa, the enzyme responsible for initiating the human coagulation cascade, and factor Xa in the common pathway of the coagulation cascade.
REFERENCES:
Capello et al. "Ancylostoma Factor Xa . . . " J. Inf. Dis. vol. 167 pp. 1474-1477 Jun., 1993.
Cappello Michael
Hawdon John M.
Hotez Peter J.
Richards Frank F.
Kim Hyosuk
Krinsky Mary M.
Wax Robert A.
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