Homologs of aprotinin produced from a recombinant host, process,

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 21, 530324, C07K 710

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active

050325736

ABSTRACT:
Microbially produced aprotinin and aprotinin homologs used for treating patients suffering from an excess release of pancreatic elastase, serum elastase or leukocyte elastase.

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Jering et al., "Replacement of Lysin by Arginine, Phenylalanine and Tryptophan in the Reactive Site of the Bovine Trypsin-K Allikrein Inhibitor (Kunitz) and Change of the Inhibitory Properties", Chemical Abstracts, vol. 84, p. 29 (1986).
Journal of Cellular Biochemistry, Suppl. 9B, 1985, Abstracts of 14th Annual Meetings, Mar. 9-Apr. 4, 1985, Marks, C. B. et al., "Expression and Mutagenesis of Bovine Pancreatic Tyrpsin Inhibitor".
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