Homologous recombination in mammalian cells

Multicellular living organisms and unmodified parts thereof and – Nonhuman animal

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4351723, 4352401, 435 691, 435 697, C12N 1500, C12N 500, C12P 2106, C12P 2104

Patent

active

057213674

ABSTRACT:
The invention relates to methods for intracellularly producing DNA segments by homologous recombination of smaller overlapping DNA fragments and transgenic mammalian cells and transgenic non-human mammals produced by such methods.

REFERENCES:
Sangos et al. Adv in Genetics 24: 285, 1987.
Lorenz et al. NAR 15(23): 9667, 1987.
Palmier et al in Genetic Manipulation, 1985, CSH pp. 123-132.
Van Zijl et al J. of Virology 62(6): 2191, 1988 Staueil et al.

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