Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1992-12-11
1995-05-09
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4352402, 4353201, 935 70, 935 71, C12N 1500, C12N 500
Patent
active
054139236
ABSTRACT:
Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, the .beta..sub.2 -microglobulin gene is inactivated for reducing or eliminating Class I MHC antigens. The resulting cells may be used as universal donors. In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts, which may be used as source of universal donor organs, or as models for drug and transplantation therapies.
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Koller Beverly H.
Kucherlapati Raju
Smithies Oliver
Billings Lucy J.
Cell Genesys Inc.
Chambers Jasemine C.
Mandel SaraLynn
Rowland Betram I.
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