Homologous recombination for universal donor cells and chimeric

Details Homologous recombination for universal donor cells and chimeric Homologous recombination for universal donor cells and chimeric

1990-11-09

1995-05-16

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4351723, 4352402, 4353201, 4353171, 800DIG1, 800DIG2, 800DIG3, 935 70, 935111, C12N 1500, C12N 500

Patent

active

054162602

ABSTRACT:
Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, the .beta..sub.2 -microglobulin gene is inactivated for reducing or eliminating Class I MHC antigens. The resulting cells may be used as universal donors. In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts, which may be used as source of universal donor organs.

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