Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1995-05-18
2000-10-31
Chambers, Jasemine
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
435455, 435463, 4353201, 435325, 514 44, C12N 1500, C12N 1563, C12N 1509
Patent
active
061398357
ABSTRACT:
Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, the .beta..sub.2- microglobulin gene is inactivated for reducing or eliminating the expression of functional Class I MHC antigens. The resulting cells may be used as allogeneic donor cells. Methods for homologous recombination in non-transformed mammalian somatic cells are also described.
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Arbones De Rafael Mariona Lourdes
Capon Daniel J.
Dubridge Robert B.
Greenburg Gary
Koller Beverly H.
Cell Genesys Inc.
Chambers Jasemine
Martin Jill D.
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