Homologous peptide nucleic acids

Details Homologous peptide nucleic acids Homologous peptide nucleic acids

2006-08-29

2006-08-29

Riley, Jezia (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S025300, C536S026600, C435S006120

Reexamination Certificate

active

07098321

ABSTRACT:
The invention discloses compounds of the formula:where n is 1, or 2 to 200 in which case each recurring unit can be the same or different,B is a protected or unprotected base capable of Watson-Crick or of Hoogsteen pairing.C is OH or OR′″ where R′″ is a protecting group or an activating group or a lipophilic group or an amino acid or amino amide or nucleoside,D is H or a protecting group or a lipophilic group or an amino acyl group or nucleoside,each of R′ and R″, which may be the same or different, is an alkyl or aryl group or R′ and R″ together represent 2 or more chain atoms necessary to complete an unsaturated or saturated ring with X and Y, said ring being optionally substituted and optionally being fused to at least one other ring,X represents and Y represents or wherein Y′ represents hydrogen or additionally, when R′ and R″ do not together complete a ring, an alkyl or aryl group, and X′, when R′ and R″ together complete a ring, represents hydrogen or forms a bridge with another atom of the ring, or when R′ and R″ do not together complete a ring, represents hydrogen or an alkyl or aryl group as well as a method of analysing a polynucleotide sequence comprising incubating the sequence with a probe comprising a compound of the above invention in which n is 2 or more under suitable hybridisation conditions, and detecting the presence or absence of any hybrid formed.

REFERENCES:
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