Homologous 28-kilodalton immunodominant protein genes of...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

Reexamination Certificate

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C424S234100, C435S069300, C435S069700, C435S091200, C435S326000, C435S340000, C536S023500, C536S023700, C514S002600, C514S012200

Reexamination Certificate

active

07344719

ABSTRACT:
The present invention is directed to the cloning, sequencing and expression of homologous immunoreactive 28-kDa protein genes, p28-1, -2, -3, -5, -6, -7, -9, from a polymorphic multiple gene family ofEhrlichia canis. Further disclosed is a multigene locus encoding all nine homologous 28-kDa protein genes ofEhrlichia canis. RecombinantEhrlichia canis28-kDa proteins react with convalescent phase antiserum from anE. canis-infected dog, and may be useful in the development of vaccines and serodiagnostics that are particularly effective for disease prevention and serodiagnosis.

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