Homogeneous mixtures of low temperature-melting drugs and additi

Details Homogeneous mixtures of low temperature-melting drugs and additi Homogeneous mixtures of low temperature-melting drugs and additi

1997-06-20

1998-09-15

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424455, 424457, 424453, 424452, A61K 948, A61K 952

Patent

active

058075747

ABSTRACT:
The present invention relates to novel compositions of and methods of manufacture of controlled release formulations obtained by mixing molten drugs with molten additives to produce homogeneous drug-additive composites.

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Bialer, M., et al., "Effect of sustained release on the pharmacokinetics of valproic acid in the dog", IJP, 20:53-63 (1984).
Bialer, M., et al., "Pharmacokinetic Evaluation of Novel Sustained-Release Dosage Forms of Valproic Acid in Humans", Biopharmaceutics & Drug Disposition, 6:401-411 (1985).
Bialer, M., et al., "Releation Between Absorption Half-Life Values of Four Novel Sustained-Release Dosage Forms of Valproic Acid in Dogs and Humans", Biopharmaceutics & Drug Disposition, 7:495-500 (1986).

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