Homogeneous isolate of urabe mumps virus and vaccines containing

Details Homogeneous isolate of urabe mumps virus and vaccines containing Homogeneous isolate of urabe mumps virus and vaccines containing

1996-01-30

1998-07-21

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4352351, 514 44, A61K 39155, C12N 700

Patent

active

057831947

ABSTRACT:
A new attenuated substantially homogeneous Urabe mumps virus strain characterized by having a codon encoding glutamic acid at amino acid position 335 of the haemagglutinin-neuraminidase (HN) protein is provided. The codon may be GAA resulting in the abolition of an MseI restriction enzyme recognition site in the native virus. The invention also provides a gene encoding the HN (Glu-335) protein. The virus has utility in attenuated mumps vaccines, and as an antigen and immunogen in diagnostic embodiments.

REFERENCES:
Brown et al. Vaccine. vol 9. Nov. 1991, pp. 840-842.

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