Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1984-11-30
1996-01-16
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
424 852, 930141, 530412, 530413, 530414, 530417, 530351, 435 6952, C07K 14545, C07K 100
Patent
active
054848873
ABSTRACT:
Interleukin 1 has been purified by use of various techniques including ion exchange chromatography and dye-ligand affinity chromatography. By these techniques, interleukin 1 has been purified to homogeneity. The high purification of interleukin 1 has enabled the amino acid composition of this protein to be ascertained and its amino acid sequence to be partially determined.
REFERENCES:
patent: 4172091 (1979-10-01), De Maeyer et al.
patent: 4406830 (1983-09-01), Fabricius et al.
patent: 4508833 (1985-04-01), Sonneborn et al.
patent: 4546161 (1985-10-01), Harvey et al.
patent: 4762914 (1988-08-01), Auron et al.
patent: 4766069 (1988-08-01), Auron et al.
patent: 4770781 (1988-09-01), Schmidt et al.
patent: 4774320 (1988-09-01), Tagliabue et al.
Sofer et al. BioTechniques Nov./Dec. 1983 pp. 198-203.
Dean et al. J. Chromatography 165, 1979, pp. 301-319.
Auron et al. PNAS 81, 1984, pp. 7907-7911.
Windle et al. J. Immunol 132, 1984, pp. 1317-1322.
Mizel, "Interleukin 1 and T Cell Activation", Immunol. Rev vol. 63, 1982, pp. 51-72.
Dye-Ligand Chromatography, Amicon Corporation (Lexington, Mass.) (1980) (Chapters 1-3).
March et al., "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs," Nature 315:641-647 (1985).
G. Blyden et al., "Purification and Properties of Human Lymphocyte Activating Factor (LAF)," 118 J. Immunol. 1631-1638 (1977).
L. B. Lachman et al., "Partial Purification of Human Lymphocyte-Activating Factor (LAF) By Ultrafiltration and Electrophoretic Techniques," 119 J. Immunol. 2019-2023 (1977).
A. Togawa et al., "Characterization of Lymphocyte-Activating Factor (LAF) Produced By Human Mononuclear Cells: Biochemical Relationship of High and Low Molecular Weight Forms of LAF," 122 J. Immunol. 2112-2118 (1979).
S. B. Mizel et al., "Characterization of Lymphocyte-Activating Factor (LAF) Produced by a Macrophage Cell Line, P388D.sub.1, II. Biochemical Characterization of LAF Induced by Activated T Cells and LPS," 120 J. Immunol. 1504-1508 (1978).
S. B. Mizel et al., "Physicochemical Characterization of Lymphocyte-Activating Factor (LAF)," 122 J. Immunol. 2167-2172 (1979).
S. B. Mizel et al., "Purification to Apparent Homogeneity of Murine Interleukin 1," 126 J. Immunol. 834-837 (1981).
P. T. Lomedico et al., "Cloning and expression of murine interleukin-1 cDNA in Escherichia coli," 312 Nature 458-462 (1984).
G. Di Sabato, "Purification and initial characterization of rat interleukin2," 79 Proc. Natl. Acad. Sci USA 3020-3023 (1982).
"Minisymposium on Regulation of Connective Tissue Cells by Immune and Inflammatory Cells," Lymphokine Res. 1(2):53 (1982).
K. Welte et al., "Purification of Human Interleukin 2 to Apparent Homogeneity and its Molecular Heterogeneity," 156 J. Exp. Med., 454-464 (1982).
O. Acuto, "An Efficient Method for Purification of Human T-Cell Growth Factor," 53 J. Immunol. Methods 15-26 (1982).
J. J. Oppenheim et al., "Interleukin 1 is more than an interleukin," T Lymphocytes Today 89-95 (1983).
L. B. Lachman, "Human interleukin 1: purification and properties," 42 Federation Proceedings 2639-2645 (1983).
A. Kock et al., "Purification of Human Interleukin 1 by High-Performance Liquid Chromatography," 296 J. Chromat. 293-300 (1984).
Matsushima et al, Lymphakine Res. Oct. 1984 p. 259 (abstract only).
C. A. Dinarello et al., PNAS 74:4624, 1977.
K. Welte et al., J. Exp. Med. 156:454, 1982.
Mosley, et al. Proc. Nat'l Acad. Sci. (USA) 84: 4572, 4576 (1987).
Conlon, III Paul J.
Hopp Thomas P.
Kronheim Shirley R.
March Carl J.
Draper Garnette D.
Immunex Corporation
Spector Lorraine M.
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