Homogeneous immunoassay system employing fourier transform infra

Details Homogeneous immunoassay system employing fourier transform infra Homogeneous immunoassay system employing fourier transform infra

1994-04-21

1996-11-26

Housel, James C.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is inorganic

25022719, 25022723, 25022727, 250340, 356 51, 356317, 356318, 356346, 356244, 422 8205, 422 8209, 422 8211, 435808, 435973, 436164, 436527, 436528, 436531, 436532, 436536, 436537, 436805, G01N 33551, G01N 33552

Patent

active

055784992

ABSTRACT:
The present invention relates to an homogeneous immunoassay system for the determination of an antibody or an antigen in a sample which consists of an interferometric signal emitted from an infrared source, a waveguide coated with an antibody or an antigen and having at least one region immersed in an aqueous sample, whereby the corresponding antigen or antibody can be complexed on the surface of the waveguide, a detector adapted to measure the interferometric signal after its propagation through the waveguide, and a measuring device to take the Fourier transform of the interferometric signal for determining the degree of attenuation of the interferometric signal at a wavelength corresponding to an absorption characteristic of an infrared label incorporated into the antigen-antibody complex, whereby determining the concentration of antigen or antibody in the sample.

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