Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1998-07-02
2000-12-26
Salimi, Ali
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241921, 424204, 424 1, 4241991, 4352351, 435 691, 435 693, 4353201, 536 2372, 536 234, A61K 3912
Patent
active
06165471&
ABSTRACT:
The present invention relates to stable HPV capsomeres which express at least one virus-neutralizing conformational epitope of a native HPV L1 protein which are substantially incapable of assembly into virus-like particles. These capsomeres, because of their smaller size, and immunogenic properties are well suited for use in HPV vaccines and as diagnostic agents. Moreover, because of their smaller size (relative to VLPs), these stable capsomeres may be easily purified and should result in HPV vaccines of enhanced homogeneity.
REFERENCES:
LI et al. J. of Virology, Apr. 1997, vol. 71, No. 4, pp. 2988-2995.
Painstil et al. Virology, 1996, vol. 223, pp. 238-244, Jan. 1996.
Garcea Robert L.
McCarthy Michael P.
Rose Robert C.
Suzich JoAnn A.
MedImmune, Inc.
Salimi Ali
University of Colorado, University Technology Corporation
University of Rochester, Office of Research and Project Administ
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