Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1982-09-16
1984-12-25
Kight, John
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
435 68, 435948, C07G 700
Patent
active
044902891
ABSTRACT:
Human interleukin 2 (IL-2) derived from induced human malignant cells has been purified to homogeneity using multiple high performance liquid chromatography (HPLC) steps. The purified IL-2 exhibits potent activity promoting the long-term in vitro culture of antigen-specific effector T-lymphocytes and in modulating lymphocyte reactivity.
REFERENCES:
patent: 4390623 (1983-06-01), Frabricius
Frank et al., J. Immun. 127, pp. 2361-2365, (1981).
Gillis et al., II. Purification of a Class of Rat and Human Lymphokines, J. Immunal 124(4), Apr. 1980, 1954-1962.
Bertoglio et al., First French Workshop on Standardization of Human Interleukin-2, Lymphokine Res. (1)(4), 1982, 121-127.
Procedures for the Purification of Interleukin 3 to Homogeneity, Ihle et al., Dec. 1982, J. of Immunol. 129(6), 2431-2436.
Quantitative Determination of Amino Acids in Tissue Culture Cells by High Performance Liq. Chrom., Kabus et al., Sep. 1982.
Isolation of Denatured Proteins and Peptides by High-Performance Liquid Chromatography, Mahoney, 1982, 284-289.
Maizel et al., Proc. Natl. Acad. Sci. U.S.A. 79, 5998, (1982).
Welte et al., J. Exp. Med. 156, p. 454, (1982).
Muraguchi et al., J. Immunol. 129, p. 2486, (1982).
DiSabato, Proc. Natl. Acad. Sci. U.S.A., vol. 79, pp. 3020-3023, May 1982.
Human Lymphotoxins; Purification to Electrophoretic Homogeneity of the .alpha.H Receptor-Bearing Class, Klostergaard et al., Mol. Immunol. 18(5), 1981, 455.
Purification to Human Alpha-Light Class Lymphotoxin to Electrophoretic Homogeneity, Mol. Immunol. 18(11), 1981, 1049, Klostergaard et al.
Third International Lymphokine Workshop: Interleukins, Lymphokins & Cytokines, Cell Immunol. 70, 1982, 380-409, Farsar et al., (Particularly p. 392 to Aune et al.).
Control of the Expression of Interleukin 2 Activity, Cell Immunol. 73(1), 1982, 106-114, Henriksen et al.
C.A. 93, 226258x, (Dec. 15, 1980).
Draper Garnette D.
Gould George M.
Hoffmann-La Roche Inc.
Kight John
Leon Bernard S.
LandOfFree
Homogeneous human interleukin 2 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Homogeneous human interleukin 2, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Homogeneous human interleukin 2 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1151899