Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1995-05-25
1997-01-28
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530412, 530416, 424 852, C07K 1455
Patent
active
055979017
ABSTRACT:
Human interleukin 2 (IL-2) derived from induced human malignant cells has been purified to homogeneity using multiple high performance liquid chromatography (HPLC) steps. The purified IL-2 exhibits potent activity promoting the long-term in vitro culture of antigen-specific effector T-lymphocytes and in modulating lymphocyte reactivity.
REFERENCES:
patent: 4778879 (1988-10-01), Mertelsmann
patent: 4925919 (1990-05-01), Mertelsmann
Welte et al. (1982) Journal of Experimental Medicine vol. 156 (2) pp. 454-464.
Mochizuki et al. (1980) Journal of Immunological Methods, vol. 39(3) pp. 185-201.
Epstein William H.
Hoffmann-La Roche Inc.
Johnston George W.
Mertz Prema
Ulm John
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