Homogeneous gene probe test using a receptor directed against th

Details Homogeneous gene probe test using a receptor directed against th Homogeneous gene probe test using a receptor directed against th

1996-09-16

1999-01-12

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 71, 536 243, 935 7, 935 77, 935 78, C12Q 168, G01N 3353, C07H 2104

Patent

active

058586687

ABSTRACT:
A homogeneous gene probe test, which is based on altering the signal of the nonhybridized gene probe by a receptor directed against the label on the gene probe is described.

REFERENCES:
patent: 4743535 (1988-05-01), Carrico
Arrand et al in Nucleic Acid Hybridization: A Practical Approach, IRL Press, Washington D.C. (1985) pp. 42-45.
W.P. Collins, "Alternative Immunoassays", John Wiley and Sons, (1985). Table of Contents.
S. L. Beaucage et al., "Tetrahedron Report Number 329", Tetrahedron, vol. 49, No. 10, (1993), pp. 1925-1963.
L. J. Arnold Jr., "Assay Formats Involving Acridinium-Easter Labeled DNA Probes", Clin. Chem., vol. 35, No. 8, (1989), pp. 1588-1594.
J. Goodchild, "Conjugates of Oligonucleotides and Modified Oligonucleotides: A Review of Their Synthesis and Properties", Bioconjugate Chemistry, vol. 1, No. 3, (May/Jun. 1990), pp. 165-187.
J. A. Matthews et al., "Enhanced Chemiluminescent Method for the Detection of DNA Dot-Hybridization Assays", Analytical Biochemistry, vol. 151, (1985), pp. 205-209.

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