Homogeneous detection methods for the determination of subpopula

Details Homogeneous detection methods for the determination of subpopula Homogeneous detection methods for the determination of subpopula

1997-09-10

2000-10-24

Wortman, Donna C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 78, 436519, 436524, 436533, G01N 33536, G01N 33546, G01N 33554

Patent

active

061365459

ABSTRACT:
The invention concerns a method for the determination of an analyte in a sample liquid wherein the sample liquid is incubated with (a) a first receptor which binds to a first epitope that is only present once on the analyte and is immobilized on a particulate carrier material and (b) a second receptor which binds to a second epitope on the analyte and has at least two binding sites for the second epitope, the first epitope being different from the second epitope and the analyte is determined by means of the binding to both receptors.

REFERENCES:
patent: 4829011 (1989-05-01), Gibbons
Database WPI on Dialog, Derwent Info. Ltd., No. 010028179 and 00635482, English abstract, EPA 617285, A and A2, Sep. 28, 1994.
International Publication No. WO 84/04396, published Nov. 8, 1984.

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