Homogeneous cyclosporin-containing solution

Details Homogeneous cyclosporin-containing solution Homogeneous cyclosporin-containing solution

2005-07-12

2005-07-12

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S785000

Reexamination Certificate

active

06916785

ABSTRACT:
Disclosed is a pharmaceutical composition suitable for oral administration in the form of a homogeneous solution which on exposure to water or gastrointestinal fluids forms an emulsion having a particle size of less than 5 microns, the solution containing:(a) a pharmaceutically effective amount of a cyclosporin, in particular Cyclosporin A(b) a carrier medium which is a triglycerol monoester of a fatty acid having from 6 to 30 carbon atoms or mixtures thereof,(c) polyethylene glycol,(d) a non-ionic surfactant having a hydrophilic lipophilic balance (HLB) greater than 10, and(e) optionally, a viscosity reducing agent, the composition being substantially free from ethanol.The preferred carrier medium is triglycerol monooleate. Examples of the viscosity reducing agent are glycerol monocaprylate and glycerol monooleate.

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patent: 2002/0009067 (2002-01-01), Sachs et al.
patent: 2002/0099067 (2002-07-01), Posanski

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