Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2007-10-16
2007-10-16
O'Hara, Eileen (Department: 1647)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C530S313000, C530S398000, C530S399000, C530S412000, C435S320100, C435S357000, C435S360000, C435S365000, C435S370000
Reexamination Certificate
active
10858928
ABSTRACT:
The present invention relates to a method for improving homogeneity and/or secretion of a recombinant protein of interest expressed in mammalian cells by replacing the endogenous signal peptide sequence of the DNA encoding the protein of interest with that of human hGH. Specifically, the present invention relates to a method wherein the protein of interest is a subunit of the follicle stimulating hormone (FSH). The invention also relates to DNA expression vectors containing the sequence encoding such proteins of interest fused to the signal peptide sequence of the hGH and to cells harbouring such vectors.
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Amitai Hagit
Chitlaru Edith
Helman Daniel
Applied Research Systems ARS Holding N.V.
Browdy & Neimark PLLC
O'Hara Eileen
Stoica Elly-Gerald
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