Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1982-08-30
1984-08-07
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, 260465D, 260465E, 562457, 560 48, 424308, 424278, 549494, A61K 3700, C07C10352, C07C12150, C07C10144, A01N 4302, A01N 3710
Patent
active
044643586
ABSTRACT:
Compounds of the formula: ##STR1## wherein R.sup.1 stands for hydrogen or a defined hydrocarbyl or halogenoalkenyl radical, R.sup.2 stands for a defined hydrocarbyl, halogenoalkenyl or furylmethyl radical, R.sup.3 is a substituent at position (a) or (b) and stands for a hydroxy or defined alkoxy or alkanoyloxy radical, R.sup.4 stands for a defined alkoxy, cyanoalkoxy or alkenyloxy radical or a defined amino acid residue or peptide residue, and n stands for 1, 2 or 3, and pharmaceutically-acceptable salts thereof. Processes for the manufacture of the compounds. Pharmaceutical compositions comprising one of the compounds and a pharmaceutical diluent or carrier. The compounds are antagonists at the opiate receptors, and most of them are selective .delta.-receptor antagonists.
REFERENCES:
S. N. Rastogi, et al., Indian Journal of Chemistry, vol. 9, (1971) 1175-1182.
Imperial Chemical Industries plc
Phillips Delbert R.
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