Homocyclic and heterocyclic compounds suitable for use in oligon

Details Homocyclic and heterocyclic compounds suitable for use in oligon Homocyclic and heterocyclic compounds suitable for use in oligon

1997-05-09

1999-03-23

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 64, 549478, 560180, C07C 6967, C07D20708, C07D30712, C07D33310

Patent

active

058861939

ABSTRACT:
A support carrying a homocyclic or heterocyclic ring containing a first and second carbon atom wherein: (i) the first carbon atom is substituted by a nucleophilic group or a group convertible to a nucleophilic group on treatment with base; (ii) the second carbon atom is substituted by a hydroxy group, a hydroxy group protected by an acid labile protecting group, or a phosphate group substituted by an oligonucleotide; and (iii) the first and second carbon atoms are directly connected by a covalent bond; which is suitable for use in oligonucleotide synthesis. Methods for its preparation and use, and novel compounds for attachment to the support are described.

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Merck Index, 10th Ed., 1983, #8928, Tannic Acid, p. 1301.
Pierce, 1989 Handbook & General Catalogue, p. 45, Heparin on TSK HW-65W.

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