Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-04-09
1999-11-09
Dentz, Bernard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514364, 514368, 514370, 514431, 514450, 546121, 548131, 548154, 548193, 548203, 549 9, 549355, A61K 3133, A61K 3138, C07D40704, C07D40904
Patent
active
059815477
ABSTRACT:
A compound having the structure: ##STR1## wherein (a) n is from about 1 to about 3;
(b) X is selected from the group consisting of O, S, SO, or SO.sub.2 ;
(c) Y is independently hydrogen or straight, branched or cyclic alkyl having from 1 to about 4 carbon atoms, or the Y's are bonded together to form an alkanyl ring having from about 3 to about 7 atoms;
(d) Z is hydrogen or straight, branched or cyclic alkyl having from 3 to about 10 atoms other than hydrogen; and
(e) Het is a heteroaryl group comprising one or more rings each ring containing from about 5 to about 6 atoms other than hydrogen and wherein the group contains at least one heteroatom selected from O, N, or S.
pharmaceutical compositions comprising such compounds, and methods of treating inflammation or pain using such compounds.
REFERENCES:
Chem. Abstract (I), A New Heterocyclic Sulfur cpd., homo-thiachroman, 1669 h, vol. 41: Abstract of Cagniant et. al., Compt. Rend, vol. 223, pp. 677-679 (1946), 1947.
Chem. Abstract II, A New Heterocyclic cpd; homochroman, vol. 44, 4470 f: Abstract of Cagniant, Compt. Rend, vol. 229, pp. 889-891 (1949), 1950.
Janusz John Michael
Wu Laurence Ichih
Dentz Bernard
McMahon Mary Pat
Roof Carl J.
Suter David L.
The Procter & Gamble & Company
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