Homeostatic organ preservation system

Details Homeostatic organ preservation system Homeostatic organ preservation system

1990-08-31

1994-07-05

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Apparatus

435 1, 435 2, 435289, 604 19, 604 31, A01N 102, C12M 136, A61N 130, A61M 100

Patent

active

053267060

ABSTRACT:
A homeostatic organ preservation system includes structure for defining a chamber for holding a donor organ, and a pump for providing a perfusion solution to the organ. A first conduit is coupled to the pump and is adapted to be coupled to the organ. The first conduit provides perfusion solution from the pump to the organ. A second conduit is coupled to the pump and to the organ chamber. The second conduit returns perfusion solution from the organ chamber to the pump. A pressure sensor is coupled to the first conduit to sense the pressure of the perfusion solution in the first conduit. The pressure sensor provides an output signal which is indicative of the vascular resistance of the organ. A pump control circuit is also included. The pump control circuit is responsive to the output signal of the pressure sensor to raise and lower the pump pulse rate respectively in response to a decrease and increase in the organ vascular resistance. A method of perfusing the donor organ, in which the organ is placed in the chamber and connected to a conduit which, in turn, is connected to a pump, includes the steps of monitoring the pressure of the perfusion solution in the conduit, and adjusting the pump pulse rate in accordance with the pressure of the perfusion solution. The pulse rate of the pump is decreased if the resistance of the perfused organ increases, and will be increased if the resistance of the perfused organ decreases.

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