Holographic sensor

Chemistry: analytical and immunological testing – Heterocyclic carbon compound – Hetero-o

Reexamination Certificate

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C436S094000, C422S068100

Reexamination Certificate

active

08048680

ABSTRACT:
A sensor for the detection of an analyte comprising a cis-diol moiety, which comprises a holographic element comprising a medium and a hologram disposed throughout the volume of the medium, wherein an optical characteristic of the element changes as a result of a variation of a physical property occurring throughout the volume of the medium, and wherein the medium is a polymer comprising a group of formula (I): wherein n is 0, 1, 2, 3 or 4; each X (if present) is independently is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom; and Y is a spacer which, when n is 0 or otherwise optionally, is an atom or group which, via an electronic effect, promotes formation of a tetrahedral geometry about the boron atom. Such a sensor may be used for the detection of glucose.

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Asher et al. ,“Photonic Crystal Carbohydrate Sensors: Low Ionic Strength Sugar Sensing”, Feb. 22, 2003, J. Am. Chem. Soc., 125, pp. 3322-3329.
Shiino et al., “Amine containing phenylboronic acid gel for glucose-responsive insulin release under physiological pH”, 1995, Journal of Controlled Release, 37, pp. 269-276.

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