Hollow polymer microcapsules and method of producing the same

Details Hollow polymer microcapsules and method of producing the same Hollow polymer microcapsules and method of producing the same

1996-12-20

1999-09-21

Dees, Jose' G.

Coating processes

Particles, flakes, or granules coated or encapsulated

Solid encapsulation process utilizing an emulsion or...

42721331, 42721336, 42840224, 428403, 424 952, 424489, 424490, 424493, 424497, 424501, B01J 1302, B32B 516, A61K 950, A61K 4904

Patent

active

059551437

ABSTRACT:
Hollow polymer microcapsules are made by the method of dissolving a film-forming polymer in a volatile nonaqueous solvent; dispersing into the polymer solution finely divided particles of a volatilizable solid core material; inducing formation of a solid polymer coating on the particulate solid core material in the nonaqueous liquid mixture to produce polymer microcapsules having an encapsulated core of particulate core material; recovering the polymer microcapsules from the nonaqueous liquid mixture; and removing the encapsulated core material from the microcapsules to make hollow polymer microcapsules. Gas-filled polymer microcapsules that are made according to the method of this invention are useful in medical applications such as imaging contrast agents because they may be prepared to precisely controlled size specifications.

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